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Which Diet Pills Really Work? With as much as 45% of overweight and 67% of obese Americans trying to lose weight [1], we should suspect that the demand for diet pills is huge.. In fact, “The U.S. Weight Loss & Diet Control Market” study found that the demand for dietary aids of all kinds reached $55 billion in 2007 alone [2].. Such high numbers mean that the market is flooded with all Bitter orange is a currently available herbal stimulant used in some weight-loss supplements and is often called an ephedra substitute. The active ingredient in bitter orange has chemical properties and actions that are similar to ephedra and may be associated with similar adverse effects. Mar 09, 2020 Jan 16, 2017 Mar 05, 2020